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in biotechnology, knowledge of biology, biochemistry, microbiology and process engineering is used to produce specific substances with new production methods, for example, in bioreactors with the aid of microorganisms. for example, a mechanical means of extracting substances is cell disruption.
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disruption of microbial cells for intracellular products yusuf chisti and murray moo-young* department of chemical engineering, university of waterloo, waterloo, ontario, canada n2l 3g i summary. disintegration of microbial cells is a necessary first step for the production of intracellular enzymes and organelies.